Cembranolides from the stem bark of the southern African medicinal plant, Croton gratissimus (Euphorbiaceae).

نویسندگان

  • Dulcie A Mulholland
  • Moses K Langat
  • Neil R Crouch
  • Helen M Coley
  • Emily M Mutambi
  • Jean-Marc Nuzillard
چکیده

The stem bark of Croton gratissimus (Euphorbiaceae) yielded four cembranolides, including the first reported example of a 2,12-cyclocembranolide, (+)-[1R*,2S*,7S*,8S*,12R*]-7,8-epoxy-2,12-cyclocembra-3E,10Z-dien-20,10-olide, whose structure was confirmed by means of single crystal X-ray analysis. This compound showed moderate activity against the PEO1 and PEO1TaxR ovarian cancer cell lines.

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Cembranolides from the leaves of Croton gratissimus.

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عنوان ژورنال:
  • Phytochemistry

دوره 71 11-12  شماره 

صفحات  -

تاریخ انتشار 2010